論文総数：178報（researchmap 2026年6月時点）。全リストは researchmap（山脇）・researchmap（岡田） をご参照ください。 Total: 178 papers (as of June 2026 on researchmap). See researchmap (Yamawaki) and researchmap (Okada) for the complete list.
※ 以下は2020年以降の主要論文36報を掲載しています。* The following lists 36 major papers published since 2020. ※ 36 selected papers from 2020 onwards are listed below.
ORIGINAL PAPERS (2020–2026)
| 著者Authors | 論文タイトルTitle | 雑誌Journal | 巻号・ページVol/Pages |
|---|---|---|---|
| (2026) | |||
| Ryo Niijima, Kosuke Otani, Tomoko Kodama, Yusei Fujioka, Muneyoshi Okada, Hideyuki Yamawaki | Minocycline inhibits endothelin-1-induced contraction in isolated pulmonary artery. | J Pharmacol Sci | 161(2): 28–31 |
| (2025) | |||
| Haru Yamamoto, Mohamed Elbadawy, … Hideyuki Yamawaki et al. | Novel organoid-based exploration reveals the role of LMTK3/FADS2 signaling in metastatic breast cancer progression in felines and humans. | Scientific Reports | 15: 45016 |
| Ko Adachi, Tomoko Kodama, Kosuke Otani, Keito Sano, Asuka Sugiyama, Muneyoshi Okada, Hideyuki Yamawaki | A selective eukaryotic elongation factor 2 kinase inhibitor, A484954 lowered blood glucose in Zucker fatty diabetes mellitus rat. | J Pharmacol Sci | 158(3): 270–275 |
| Yusei Fujioka, Kosuke Otani, Muneyoshi Okada, Hideyuki Yamawaki | Senescent cardiac fibroblasts-derived extracellular vesicles induced autophagy in cardiac fibroblasts via suppression of ras homolog enriched in brain like 1. | J Pharmacol Sci | 158(1): 1–7 |
| Kosuke Otani, Yusei Fujioka, Muneyoshi Okada, Hideyuki Yamawaki | Development of an Effective Isolation Method for Plasma Extracellular Vesicles Excluding Lipoproteins by Precipitation With Polyethylene Glycol. | J Extracell Biol | 4(4): e70047 |
| R Baba, D Ito, T Toyofuku, H Ichihashi, N Arizuka, Muneyoshi Okada | Accuracy of visually estimated left heart size by echocardiography in dogs with myxomatous mitral valve disease. | J Vet Cardiol | 61: 1–9 |
| Yuko Nagashima, Haru Yamamoto, Mohamed Elbadawy, … Hideyuki Yamawaki et al. | Establishment of an experimental model of canine apocrine gland anal sac adenocarcinoma organoid culture. | Scientific Reports | 15(1): 6108 |
| Mohamed Elbadawy, Nagisa Saito, … Hideyuki Yamawaki et al. | Establishment of a bat lung organoid culture model for studying bat-derived infectious diseases. | Scientific Reports | 15(1): 4035 |
| Hideyuki Yamawaki, Tetsuo Nakata | Editorial on recent trends in the pharmacology of cardiovascular diseases. | J Pharmacol Exp Ther | 392(2): 103384 |
| Tomoko Kodama, Satoshi Kameshima, Kosuke Otani, Muneyoshi Okada, Hideyuki Yamawaki | The eukaryotic elongation factor 2 kinase inhibitor, A484954, induces hypoglycaemic and hypotensive effects. | Br J Pharmacol | 182(8): 1823–1835 |
| Hayato Sasaki, Kazuki Otake, … Kosuke Otani, Hideyuki Yamawaki et al. | Protective function of the voltage-gated potassium channel Kv11.3 in a mouse model of cardiac ischemia/reperfusion injury. | PLoS One | 20(5): e0323428 |
| Ryo Niijima, Kosuke Otani, Tomoko Kodama, Muneyoshi Okada, Hideyuki Yamawaki | Minocycline prevents monocrotaline-induced pulmonary hypertension through the attenuation of endothelial dysfunction and vascular wall thickening. | J Pharmacol Sci | 157(1): 39–44 |
| (2024) | |||
| Kosuke Otani, Naofumi Uemura, Hiroshi Funada, Tomoko Kodama, Muneyoshi Okada, Hideyuki Yamawaki | Alteration of reactivity in isolated mesenteric artery from Zucker fatty diabetes mellitus rats. | J Pharmacol Sci | 156(1): 38–44 |
| Yuta Okamura, Ko Adachi, Ryo Niijima, Tomoko Kodama, Kosuke Otani, Muneyoshi Okada, Hideyuki Yamawaki | Human omentin-1 reduces vascular insulin resistance and hypertension in Otsuka Long-Evans Tokushima Fatty rats. | Naunyn Schmiedebergs Arch Pharmacol | 397: 3379–3387 |
| (2023) | |||
| Yusei Fujioka, Kosuke Otani, Tomoko Kodama, Muneyoshi Okada, Hideyuki Yamawaki | Autocrine role of senescent cardiac fibroblasts-derived extracellular vesicles. | J Vet Med Sci | 85(11): 1157–1164 |
| Tomoko Kodama, Kosuke Otani, Muneyoshi Okada, Hideyuki Yamawaki | Eukaryotic elongation factor 2 kinase inhibitor, A484954 induced diuresis via nitric oxide production in spontaneously hypertensive rats. | J Vet Med Sci | 85(12): 1314–1318 |
| Satoshi Kameshima, Yuki Nakamura, … Hideyuki Yamawaki et al. | Effects of a Soluble Guanylate Cyclase Stimulator Riociguat on Contractility of Isolated Pulmonary Artery and Hemodynamics of U46619-Induced Pulmonary Hypertension in Dogs. | Vet Sci | 10(2): 159 |
| Yuta Okamura, Ryo Niijima, Satoshi Kameshima, Tomoko Kodama, Kosuke Otani, Muneyoshi Okada, Hideyuki Yamawaki | Human Omentin-1 Administration Ameliorates Hypertensive Complications without Affecting Hypertension in Spontaneously Hypertensive Rats. | Int J Mol Sci | 24(4): 3835 |
| Mohamed Elbadawy, Kiwamu Tanabe, … Hideyuki Yamawaki et al. | Evaluation of the efficacy of mitochondrial fission inhibitor (Mdivi-1) using non-alcoholic steatohepatitis (NASH) liver organoids. | Front Pharmacol | 14: 1243258 |
| (2022) | |||
| Atsunori Yamamoto, Tomoko Kodama, Kosuke Otani, Muneyoshi Okada, Hideyuki Yamawaki | Chemerin fragments show different effects on systemic blood pressure dependent on carboxyl-terminal cleavage site. | J Vet Med Sci | 84(10): 1352–1357 |
| Tomoko Kodama, Kosuke Otani, Muneyoshi Okada, Hideyuki Yamawaki | Eukaryotic elongation factor 2 kinase inhibitor, A484954 inhibits perivascular sympathetic nerve stimulation-induced vasoconstriction in isolated renal artery. | Eur J Pharmacol | 926: 175042 |
| Kosuke Otani, Hiroshi Funada, Risa Teranishi, Muneyoshi Okada, Hideyuki Yamawaki | Cardiovascular Characteristics of Zucker Fatty Diabetes Mellitus Rats, an Animal Model for Obesity and Type 2 Diabetes. | Int J Mol Sci | 23(8): 4228 |
| (2021) | |||
| Tomoko Kodama, Satoshi Kameshima, Kosuke Otani, Muneyoshi Okada, Hideyuki Yamawaki | Eukaryotic elongation factor 2 kinase inhibitor, A484954 induces diuretic effect via renal vasorelaxation in spontaneously hypertensive rats. | Eur J Pharmacol | 913: 174637 |
| Atsunori Yamamoto, Ayumi Sagara, Kosuke Otani, Muneyoshi Okada, Hideyuki Yamawaki | Chemerin-9 stimulates migration in rat cardiac fibroblasts in vitro. | Eur J Pharmacol | 912: 174566 |
| Atsunori Yamamoto, Kosuke Otani, Muneyoshi Okada, Hideyuki Yamawaki | Chemokine-like Receptor 1 in Brain of Spontaneously Hypertensive Rats Mediates Systemic Hypertension. | Int J Mol Sci | 22(21): 11812 |
| Akira Sugiyama, Yurie Shimizu, Muneyoshi Okada, Kosuke Otani, Hideyuki Yamawaki | Preventive Effect of Canstatin against Ventricular Arrhythmia Induced by Ischemia/Reperfusion Injury. | Int J Mol Sci | 22(3): 1004 |
| Akira Sugiyama, Muneyoshi Okada, Kosuke Otani, Hideyuki Yamawaki | Development of basic research toward clinical application of cleaved fragment of type IV collagen. (Review) | Folia Pharmacol Jpn | 156(5): 282–287 |
| Tomoko Kodama, Kosuke Otani, Muneyoshi Okada, Hideyuki Yamawaki | Age-dependent increase in activity of eukaryotic elongation factor 2 kinase in mesenteric arteries from spontaneously hypertensive rats. | J Vet Med Sci | 83(1): 42–47 |
| Keisuke Imoto, Yuho Sakai, Muneyoshi Okada, Kosuke Otani, Hideyuki Yamawaki | A single injection of periostin decreases cardiac voltage-gated Na+ channel in rat ventricles. | J Vet Med Sci | 83(6): 916–921 |
| (2020) | |||
| Akira Sugiyama, Rumi Ito, Muneyoshi Okada, Hideyuki Yamawaki | Long-term administration of recombinant canstatin prevents adverse cardiac remodeling after myocardial infarction. | Scientific Reports | 10: 12881 |
| Tomoko Kodama, Muneyoshi Okada, Hideyuki Yamawaki | Eukaryotic elongation factor 2 kinase inhibitor, A484954 lowered blood pressure in spontaneously hypertensive rats via inducing vasorelaxation. | J Pharmacol Sci | 144(3): 165–171 |
| Yusei Fujioka, Kosuke Otani, Muneyoshi Okada, Hideyuki Yamawaki | Plasma small extracellular vesicles in hypertensive rats impair reactivity of isolated blood vessels. | J Vet Med Sci | 82(7): 897–902 |
| Atsunori Yamamoto, Kengo Matsumoto, … Muneyoshi Okada, Hideyuki Yamawaki | Acute intracerebroventricular injection of chemerin-9 increases systemic blood pressure through activating sympathetic nerves via CMKLR1 in brain. | Pflugers Arch Eur J Physiol | 472(6): 673–681 |
| Kosuke Otani, Mai Yokoya, Yusei Fujioka, Muneyoshi Okada, Hideyuki Yamawaki | Small extracellular vesicles from rat plasma promote migration and proliferation of vascular smooth muscle cells. | J Vet Med Sci | 82(3): 299–306 |
| Keisuke Imoto, Momoko Aratani, Takahiro Koyama, Muneyoshi Okada, Hideyuki Yamawaki | Thrombospondin-4 induces prolongation of action potential duration in rat isolated ventricular myocytes. | J Vet Med Sci | 82(6): 707–712 |
| Ayaho Omori, … Muneyoshi Okada, Hideyuki Yamawaki | Chemerin-9-induced contraction was enhanced through the upregulation of smooth muscle chemokine-like receptor 1 in isolated pulmonary artery of pulmonary arterial hypertensive rats. | Pflugers Arch Eur J Physiol | 472(3): 335–342 |
CONFERENCE PRESENTATIONS（抜粋：2024–2026）
| # | 学会・発表Conference & Presentation | 年Year | 形式Type |
|---|---|---|---|
| 1 | 第99回日本薬理学会年会（仙台）99th Annual Meeting of JPS, Sendai シンポジウム1件、ポスター2件1 symposium, 2 posters | 2026 | Symposium / Poster |
| 2 | 第3回北里研究者サミット（白金）3rd Kitasato Researcher Summit, Shirokane ポスター1件1 poster | 2026 | Poster |
| 3 | 第4回カルシウムセンシタイザー研究会（ステーションコンファレンス東京、ハイブリッド）4th Calcium Sensitizer Research Meeting, Tokyo (hybrid) 招待講演（共催：第46回日本臨床薬理学会学術総会）Invited lecture (co-hosted: 46th JSCPT Annual Meeting) | 2025 | Invited |
| 4 | 第35回日本循環薬理学会（米子）35th Japanese Society of Cardiovascular Pharmacology, Yonago 口頭1件1 oral | 2025 | Oral |
| 5 | 第76回日本薬理学会北部会76th JPS Hokkaido Branch Meeting 口頭2件（うち1件は西宮機能系基礎医学研究助成金受賞講演）2 orals (incl. 1 Nishimiya Award lecture) | 2025 | Oral |
| 6 | 第168回日本獣医学会学術集会（宮崎大学）168th JSVS Annual Meeting, Miyazaki University 口頭1件1 oral | 2025 | Oral |
| 7 | 第38回北里大学バイオサイエンスフォーラム38th Kitasato University Bioscience Forum 口頭2件、ポスター1件2 orals, 1 poster | 2025 | Oral / Poster |
| 8 | ISEV2025 Annual Meeting（オーストリア）ISEV2025 Annual Meeting, Austria | 2025 | Poster |
| 9 | APPW2025 / 第98回日本薬理学会年会（千葉）APPW2025 / 98th Annual Meeting of JPS, Chiba YIA1件、ポスター1件1 YIA, 1 poster | 2025 | YIA / Poster |
| 10 | 第7回日本獣医薬理学・毒性学会 春季研究会（麻布大学）7th JSVPT Spring Meeting, Azabu University 口頭3件3 orals | 2025 | Oral |
| 11 | 第34回日本循環薬理学会（静岡）34th JSCP, Shizuoka 口頭1件1 oral | 2024 | Oral |
| 12 | 第75回日本薬理学会北部会（盛岡）75th JPS Hokkaido Branch Meeting, Morioka 口頭1件1 oral | 2024 | Oral |
| 13 | 第167回日本獣医学会学術集会（帯広畜産大学）167th JSVS Annual Meeting, Obihiro University 口頭6件6 orals | 2024 | Oral |
| 14 | 第37回北里大学バイオサイエンスフォーラム37th Kitasato University Bioscience Forum 口頭9件9 orals | 2024 | Oral |
| 15 | 第6回日本獣医薬理学・毒性学会 春季研究会（北里大学 十和田キャンパス・主催）6th JSVPT Spring Meeting, Kitasato University Towada (hosted) | 2024 | Oral (hosted) |
| 16 | 第33回日本循環薬理学会33rd JSCP 口頭2件2 orals | 2024 | Oral |
AWARDS & GRANTS
| 年度Year | 種別Type | 内容Detail |
|---|---|---|
| AWARDS — 受賞 | ||
| 2025 | 助成 | 西宮機能系基礎医学研究助成金Nishimiya Foundation Award for Basic Medicine |
| 2023 | 受賞 | 第74回日本薬理学会北部会 優秀発表賞Excellence Award, 74th JPS Hokkaido Branch Meeting |
| 2023 | 受賞 | 第32回日本循環薬理学会 Young Investigator Award（YIA）Young Investigator Award, 32nd JSCP |
| 2022–2023 | 受賞 | 日本獣医学会 獣医学奨励賞（2022–2023年度）JSVS Encouragement Award (2022–2023) |
| 2021–2022 | 受賞 | 日本獣医学会 獣医学奨励賞（2021–2022年度）JSVS Encouragement Award (2021–2022) |
| 2018 | 受賞 | 第33回日本薬理学会学術奨励賞33rd JPS Academic Encouragement Award |
| 2013 | 受賞 | 第155回日本獣医学会 優秀ポスター賞Excellent Poster Award, 155th JSVS |
| 2012 | 受賞 | 第153回日本獣医学会 獣医学奨励賞JSVS Encouragement Award, 153rd |
| 2012 | 受賞 | 第32回日本循環薬理学会 Young Investigator Award（YIA）YIA, 32nd JSCP |
| GRANTS — 競争的資金（科研費） | ||
| 2026–2029 | 科研費 | 山脇英之（代表）：基盤研究(B)「機械ストレスによる新たな動脈硬化症の病態制御機構：細胞外小胞に着目した検討」Yamawaki H (PI): KAKENHI Grant-in-Aid (B) — Extracellular vesicles in mechanical stress-induced atherosclerosis |
| 2025–2028 | 科研費 | 岡田宗善（代表）：基盤研究(C)「糖尿病合併症における基底膜IV型コラーゲン由来matricryptinsの役割解明」Okada M (PI): KAKENHI Grant-in-Aid (C) — Matricryptins in diabetic complications |
| 2021–2024 | 科研費 | 山脇英之（代表）：基盤研究(B)「エクソソームに着目した本態性高血圧症の新たな病態機序の解明」Yamawaki H (PI): KAKENHI Grant-in-Aid (B) — Exosomes in essential hypertension |
| 2022–2025 | 科研費 | 岡田宗善（代表）：基盤研究(C)「粘液腫様僧帽弁疾患におけるmatricryptinsを介した新規発症機構解明」Okada M (PI): KAKENHI Grant-in-Aid (C) — Matricryptins in MMVD |
| 2022–2024 | 科研費 | 山脇英之（代表）：挑戦的研究(萌芽)「細胞外小胞を介したshear stressによる新たな動脈硬化制御機構の解明」Yamawaki H (PI): KAKENHI Challenging Research (Exploratory) — Shear stress-induced EV-mediated atherosclerosis |
| 2019–2022 | 科研費 | 岡田宗善（代表）：基盤研究(C)「基底膜IV型コラーゲンα1鎖分解断片arrestenの心臓における役割」Okada M (PI): KAKENHI Grant-in-Aid (C) — Arresten in cardiac disease |
| 2017–2020 | 科研費 | 山脇英之（代表）：基盤研究(B)「アディポサイトカインによる脳-心-腎-血管連関調節を介した真の心血管病制御機構」Yamawaki H (PI): KAKENHI Grant-in-Aid (B) — Adipocytokines in cardiovascular regulation |
| 2016–2018 | 科研費 | 岡田宗善（代表）：基盤研究(C)「心疾患病態形成におけるIV型コラーゲン分解産物カンスタチンの役割解明」Okada M (PI): KAKENHI Grant-in-Aid (C) — Canstatin in cardiac pathology |
| 2014–2015 | 科研費 | 岡田宗善（代表）：基盤研究(C)「心疾患におけるエンドスタチンの病態生理的役割の解明」Okada M (PI): KAKENHI Grant-in-Aid (C) — Endostatin in cardiac disease |
| 2013–2016 | 科研費 | 山脇英之（代表）：基盤研究(B)「新規アディポサイトカインによる動脈硬化症の病態制御機構の全体像を解明する」Yamawaki H (PI): KAKENHI Grant-in-Aid (B) — Adipocytokines in atherosclerosis |
| 2013–2014 | 科研費 | 山脇英之（代表）：挑戦的萌芽研究「血管慢性炎症性変化の再構築による動脈硬化発症機序の時空間的解析」Yamawaki H (PI): KAKENHI Challenging Exploratory Research — Spatiotemporal analysis of vascular atherosclerosis |
| 2012–2013 | 科研費 | 岡田宗善（代表）：基盤研究(C)「心臓リモデリングにおけるmatricryptinsの作用に関する基礎的検討」Okada M (PI): KAKENHI Grant-in-Aid (C) — Matricryptins in cardiac remodeling |