2026
Phenotypic characterization of Signature-Tagged mutants identifies physiological determinants ofVibrio vulnificusfitness.Yamazaki, K., Kado, T., Kashimoto, T. bioRxivs doi: https://doi.org/10.64898/2025.12.18.695119.
Nutrient acquisition drivesEdwardsiella tardapathogenesis in necrotizing soft tissue infection.Yamazaki, K., Yamaguchi, T., Yokoyama, Y., Tonosaki, Y., Kursanbaeva, K., Motooka, D., Akeda, Y., Kashimoto, T. mSystems. 2026. 10.1128/msystems.01657-25
A new mouse model of typhoid fever usingSalmonella entericaserovar Paratyphi C as a surrogate pathogen.Pham, HT., Morita, M., Yamazaki, K., Endo, T., Takayama, S., Hiyoshi, A., Haneda, T., Tsolis, RM., Bäumler, AJ., Kodama, T., Hiyoshi, H. mBio. 2026.10.1128/mbio.03622-2

2025
Clinical and molecular characteristics of urinary catheter-associatedPseudomonas aeruginosaprostatic infection: A case series of four postoperative nosocomial infections.Fukushima S, Sano T, Kashimoto T, Hagiya H. J. Infect. Chemother. 2025. 102853 doi.org/10.1016/j.jiac.2025.102853

2024
High fat intake sustains sorbitol intolerance after antibiotic-mediatedClostridiadepletion from the gut microbiota.Lee, JY., Tiffany, CR., Mahan, SP., Kellom, M., Rogers, AWL., Nguyen, H., Stevens, ET., Masson, HLP., Yamazaki, K., Marco, ML., Eloe-Fadrosh, EA., Turnbaugh, PJ., and Bäumler, AJ. Cell. 2024.29;187(5):1191-1205.e15. doi: 10.1016/j.cell.2024.01.029. Epub 2024 Feb 15.
Salmonellare-engineers the intestinal environment to break colonization resistance in the presence of a compositionally intact microbiota.Rogers, AWL., Radlinski, LC., Nguyen, N., Tiffany, CR., Carvalho, TP., Masson, HLP., Goodson, ML., Bechtold, L., Yamazaki, K., Liou, MJ., Miller, BM., Mahan, SP., Young, BM., Demars, AM., Gretler, SR., Larabi, AB., Lee, JY., Bays, DJ., Tsolis, RM., Bäumler, AJ. Cell host & microbe. 2024. 10.1016/j.chom.2024.07.02
Characterization of Outer Membrane Vesicles Produced byVibrio vulnificus.Higashiyama, R., Kanda, Y., Shimohata, T., Ishida, K., Fukushima, S., Yamazaki, K., Uebanso, T., Mawatari, K., Kashimoto, T., Takahashi A. J. Med. Invest. 2024.71:102-112

2023
Characteristic metabolic changes in skeletal muscle due toVibrio vulnificusinfection in a wound infection model.Ishida, K., Shimohata, T., Kanda, Y., Nguyen, A., Q., Masuda, R., Yamazaki, K., Uebanso, T., Mawatari, K., Kashimoto, T., Takahashi, A. mSystems. 2023.8(2):e0068222.

2022
Increased vascular permeability due to spread and invasion ofVibrio vulnificusin the wound infection exacerbates potentially fatal necrotizing disease.Yamazaki, K., Kashimoto, T., Kado, T., Yoshioka, K., Ueno, S. Front. Microbiol. 2022.13: 849600-849600.
Reversible modification of mitochondrial ADP/ATP translocases by pairedLegionellaeffector proteins.Kubori, T., Lee, J., Kim, H., Yamazaki, K., Nishikawa, M., Kitao, T., Oh, BH., and Nagai, H. Proc. Natl. Acad. Sci. U. S. A. 2022.119(23) e2122872119
Synthetic engineering and biological containment of bacteriophages.Mitsunaka, S., Yamazaki, K., Pramono, A.,K., Ikeuchi, M., Kitao, T., Ohara, N., Kubori, T., Nagai, H., and Ando, H. Proc. Natl. Acad. Sci. U. S. A. 2022.119(48):e2206739119.

2021
MukB Is a Gene Necessary for Rapid Proliferation ofVibrio vulnificusin the Systemic Circulation but Not at the Local Infection Site in the Mouse Wound Infection Model.
Kashimoto T, Yamazaki K, Kado T, Matsuda K, Ueno S. Microorganisms. 2021 Apr 27;9(5):934. doi: 10.3390/microorganisms9050934.
V. vulnificusのMukBは、創傷感染局所でのV. vulnificusの増殖には影響を与えず、全身循環へ侵入後の増殖に必要な因子 　であることを発見した。敗血症発症後の増殖にのみ必要な因子として初めての報告となった。
Expansion of Necrosis Depending on Hybrid Motor-Driven Motility ofAeromonas hydrophilain a Murine Wound Infection Model.
Yamazaki K, Kashimoto T, Niwano A, Yamasaki M, Nomura M, Akeda Y, Ueno S. 　Microorganisms. 2020 Dec 22;9(1):10. doi: 10.3390/microorganisms901001.
A. hydrophilaの持つハイブリッドべん毛モーターが壊死の拡大に必要であることを示した。
New inducible mast cell-deficient mouse model (Mcpt5/Cma1D TR) .
Sasaki H, Imanishi M, Fujikura D, Sugiyama M, Tanimoto K, Mochiji Y, Takahashi Y, Hiura K, Watanabe M, Kashimoto T, Nakano K　Okamura T, Sasaki N　Biochem Biophys Res Commun. 2021 Apr 30;551:127-132. doi: 10.1016/j.bbrc.2021.03.025.
Transcriptional inhibition of feline immunodeficiency virus by alpha-amanitin.
Tanabe T, Fukuda Y, Kawashima K, Yamamoto S, Kashimoto T, Sato H.J Vet Med Sci. 2021 Jan 21;83(1):158-161. doi:10.1292/jvms.20-0182.

2020
Chemotactic invasion in deep soft tissue byVibrio vulnificusis essential for the progression of necrotic lesions.　Yamazaki K, Kashimoto T, Kado T, Akeda Y, Yoshioka K, Kodama T, Yamamoto M, Okamura M, Kakuda 　　T, Ueno S.　 Virulence. 2020 Dec;11(1):840-848. doi: 10.1080/21505594.2020.1782707. (IF:5.54) 　
V. vulnificus 感染により発症する筋肉組織の壊死には、V. vulnificusの化学走化性が必要であることを証明した。
Vibro vulnificushemolysin associates with gangliosides.　Kashimoto T, Sugiyama H, Kawamidori K, Yamazaki K, Kado T, Matsuda K, Kodama T, Mukai T, 　Ueno S.　BMC Microbiol. 2020 Mar 30;20(1):69. doi: 10.1186/s12866-020-01755-1. (IF:3.3)
Structural basis for effector protein recognition by the Dot/Icm Type IVB coupling protein complex 　Kim H, Kubori T,Yamazaki K, Kwak MJ, Park SY, Nagai H, Vogel JP, Oh BH.　Nat Commun. 2020 May 26;11(1):2623. doi: 10.1038/s41467-020-16397-0.　
Vibrio vulnificusの分泌する溶血毒素の細胞受容体がガングリオシドであることを示した。

2019
Identification of in vivo Essential Genes of Vibrio vulnificus for Establishment of Wound Infection by Signature-Tagged Mutagenesis. 　Yamazaki K, Kashimoto T, Morita M, Kado T, Matsuda K, Yamasaki M, Ueno S.　Front Microbiol. 2019 Feb 1;10:123. doi: 10.3389/fmicb.2019.00123. (IF:4.1)　
Siganture tagged mutagenesis法により、Vibrio vulnificusが創傷感染時に必須とする遺伝子を網羅的に同定した。
Accurate prediction of anti-phagocytic activity of Vibrio vulnificus by measurement of bacterial adherence to hydrocarbons. Prediction of Anti-Phagocytic Activity. Kado T, Kashimoto T, Yamazaki K, Matsuda K, Ueno S.　APMIS. 2019 Feb;127(2):80-86. doi: 10.1111/apm.12910. (IF:2.0)
Vibrio vulnificus菌体表面の疎水度の変化により、高精度に貪食抵抗性が予測できることを示した。

2018
Immunogenicity and protective efficacy ofVibrio vulnificusflagellin protein FlaB in a wound infection model. Yamazaki K, Kashimoto T, Hashimoto Y, Kado T, Ueno S.　J Vet Med Sci. 2018 Jan 1;80(1):55-58. doi: 10.1292/jvms.17-0395. (IF:0.7)
Vibrio vulnificusのべん毛構成タンパク質であるFlaBの免疫により、感染局所における感染防御効果の可能性を示した。

2017
Both polarity and aromatic ring in the side chain of tryptophan 246 are involved in binding activity ofVibrio vulnificushemolysin to target cells. Kashimoto T, Akita T, Kado T, Yamazaki K, Ueno S.　Microb Pathog. 2017 Aug;109:71-77. doi: 10.1016/j.micpath.2017.05.029. (IF:2.0)
Vibrio vulnificusの産生するVVHの246残基目Trpの極性と芳香環の両方が細胞への結合活性に重要であることを見出した。
Importance of fumarate and nitrate reduction regulatory protein for intestinal proliferation of Vibrio vulnificus . Kado T, Kashimoto T, Yamazaki K, Ueno S.　FEMS Microbiol Lett. 2017 Jan;364(1):fnw274. doi: 10.1093/femsle/fnw274.(IF:1.8) 　
Vibrio vulnificusの腸管内での増殖に嫌気呼吸へのスイッチング分子であるFNRが必要であることを見出した。

2016
A silkworm infection model to investigateVibrio vulnificusvirulence genes. Yamamoto M, Kashimoto T, Yoshimura Y, Tachibana N, Kuroda S, Miki Y, Kitabayashi S, Tong P, Xiao J, Tanaka K, Hamamoto H, Sekimizu K, Yamamoto K.　Mol Med Rep. 2016 Nov;14(5):4243-4247. doi: 10.3892/mmr.2016.5782.

2015
Vibrio vulnificusdetected in the spleen leads to fatal outcome in a mouse oral infection model. Kashimoto T, Iwasaki C, Gojo M, Sugiyama H, Yoshioka K, Yamamoto Y, Okamura M, Susa N, Ueno S.　FEMS Microbiol Lett. 2015 Apr;362(7):fnv0005. doi: 10.1093/femsle/fnv005. (IF:1.8) 　
Vibrio vulnificusの経口感染モデルを用い、脾臓での感染菌のクリアランスが生死を分けることを示した。
Signature-tagged mutagenesis ofVibrio vulnificus. Yamamoto M, Kashimoto T, Tong P, Xiao J, Sugiyama M, Inoue M, Matsunaga R, Hosohara K, Nakata K, Yokota K, Oguma K, Yamamoto K.　J Vet Med Sci. 2015 Jul;77(7):823-8. doi: 10.1292/jvms.14-0655.

2014
TheVibrio parahaemolyticuseffector VopC mediates Cdc42-dependent invasion of cultured cells but is not required for pathogenicity in an animal model of infection. Okada R, Zhou X, Hiyoshi H, Matsuda S, Chen X, Akeda Y, Kashimoto T, Davis BM, Iida T, Waldor MK, Kodama T.　Cell Microbiol. 2014 Jun;16(6):938-47. doi: 10.1111/cmi.12252.

2013
Future diagnosis and treatment ofVibrio vulnificusinfection based on its pathogenesis. Kashimoto T. 　Antibioitics and chemotherapy. 2013 29(7):87-94. Review.Vibrio vulnificusの病原性研究の進捗とそこから見た治療の可能性について述べた。 Inhibition of Binding of Vibrio vulnificus Hemolysin (VVH) by MβCD. Sugiyama H, Kashimoto T, Ueno S, Susa N.　J Vet Med Sci. 2013 75(5), 649-52. (IF:0.7)　
V.vulnificusの産生するVVHの細胞への結合が糖によって阻害されることを発見した。

2012
Immunization with outer membrane protein A fromSalmonella entericaserovar Enteritidis induces humoral immune response but no protection against homologous challenge in chickens. Okamura M, Ueda M, Noda Y, Kuno Y, Kashimoto T, Takehara K, Nakamura M.　Poult Sci. 2012 Oct;91(10):2444-9. doi: 10.3382/ps.2012-02303.

2011
Relationship between localization on cellular membranes and cytotoxicity ofVibrio vulnificushemolysin. Sugiyama H, Kashimoto T, Ueno S, Ehara H, Kodama T, Iida T, Susa N.　PLoS One. 2011;6(10):e26018. doi: 10.1371/journal.pone.0026018. (IF:4.5)　
Vibrio vulnificus hemolysin の細胞膜上における局在と細胞毒性が無関係であることを示した。
Current status and future prospects in a pathogenic study ofVibrio vulnificus. Kashimoto T.　Nihon Saikingaku Zasshi. 2010 Dec;65(2-4):369-78. doi: 10.3412/jsb.65.369.　Review　Vibrio vulnificusの病原性研究の現状を病原性の面から概説し、病原性研究の問題点を述べた。