研究業績

Parasit Vectors. 2022 Jul 8;15(1):244. doi: 10.1186/s13071-022-05357-w.
Plasmodium berghei Brca2 is required for normal development and differentiation in mice and mosquitoes.
Yasunaga Y, Shunta K, Akira S, Makoto S, Aki U, Hiroki K, Zida Z, Kazuhiko O, Kazuhiko N, Jun H, Kodai K, Asako H, Taisuke K, Koichi O, Shinya F, Hiromi I.

Int J Mol Sci. 2022 Apr 6;23(7):4060. doi: 10.3390/ijms23074060.
BRCA2 C-Terminal RAD51-Binding Domain Confers Resistance to DNA-Damaging Agents.
Zida Z, Taisuke K, Masami M, Arisa T, Ryo M, Xianghui L, Koichi O, Yasunaga Y.

BMC Mol Cell Biol. 2021 Jan 6;22(1):2. doi: 10.1186/s12860-020-00336-4.
Reduced translation efficiency due to novel splicing variants in 5' untranslated region and identification of novel cis-regulatory elements in canine and human BRCA2
Yoshikawa Y, Kozuma H, Morimatsu M, Sugawara K, Orino K.

J Vet Med Sci. 2021 May 9;83(5):759-766. doi: 10.1292/jvms.21-0006. Epub 2021 Mar 16.
Identification of the core motif of the BRCA2 C-terminal RAD51-binding domain by comparing canine and human BRCA2.
Yoshikawa Y, Morimatsu M, Ochiai K, Ishiguro-Oonuma T, Morioka R, Okuda K, Orino K.

International Dairy Journal 105 104690
Binding analysis of bovine milk proteins, especially casein interactions and the interaction between α-casein and lactoferrin, using beads immobilized with zinc ion and poly-L-lysine or α-casein.
Naito K, Iio T, Katagi M, Yoshikawa Y, Ohtsuka H, Orino K.

Vet Comp Oncol. 2020 Jun;18(2):247-255. doi: 10.1111/vco.12542. Epub 2019 Sep 13.
The canine RAD51 mutation leads to the attenuation of interaction with PALB2.
Uemura M, Ochiai K, Morimatsu M, Michishita M, Onozawa E, Azakami D, Uno Y, Yoshikawa Y, Sasaki T, Watanabe M, Omi T.

Cell Rep. 2019 Jun 4;27(10):2990-3005.e5. doi: 10.1016/j.celrep.2019.05.003.
Phosphorylation of FANCD2 Inhibits the FANCD2/FANCI Complex and Suppresses the Fanconi Anemia Pathway in the Absence of DNA Damage.
Lopez-Martinez D, Kupculak M, Yang D, Yoshikawa Y, Liang CC, Wu R, Gygi SP, Cohn MA.

Biometals. 2018 Feb;31(1):131-138. doi: 10.1007/s10534-017-0075-1. Epub 2017 Dec 28.
Heme-binding of bovine lactoferrin: the potential presence of a heme-binding capacity in an ancestral transferrin gene.
Saito N, Iio T, Yoshikawa Y, Ohtsuka H, Orino K.

Biometals. 2PLoS Genet. 2018 Oct 18;14(10):e1007643. doi: 10.1371/journal.pgen.1007643. eCollection 2018 Oct.
Identification of UHRF2 as a novel DNA interstrand crosslink sensor protein.
Motnenko A, Liang CC, Yang D, Lopez-Martinez D, Yoshikawa Y, Zhan B, Ward KE, Tian J, Haas W, Spingardi P, Kessler BM, Kriaucionis S, Gygi SP, Cohn MA.

EMS Vet Sci J 1(1):1.
Changes in anti-Ferritin autoantibody during pregnancy in rats.
Hasegawa R, Kiyota H, Kurusu S, Yoshikawa Y, Orino K.

Biometals. 2017 Aug;30(4):615-621. doi: 10.1007/s10534-017-0032-z. Epub 2017 Jul 4.
Inhibitory effect of transferrin on serum zinc measurement.
Orino K.

Biometals. 2016 Feb;29(1):15-24. doi: 10.1007/s10534-015-9897-x. Epub 2015 Nov 26.
Physiological implications of mammalian ferritin-binding proteins interacting with circulating ferritin and a new aspect of ferritin- and zinc-binding proteins.
Orino K.

Front Vet Sci. 2015 May 26;2:12. doi: 10.3389/fvets.2015.00012. eCollection 2015.
Iron and Ferritin Levels in the Serum and Milk of Bovine Leukemia Virus-Infected Dairy Cows.
Schnell SA1, Ohtsuka H2, Kakinuma S3, Yoshikawa Y1, Watanabe K1, Orino K1.

Vet J. 2015 Nov;206(2):143-8. doi: 10.1016/j.tvjl.2015.08.002. Epub 2015 Aug 7.
Molecular cloning of canine co-chaperone small glutamine-rich tetratricopeptide repeat-containing protein α (SGTA) and investigation of its ability to suppress androgen receptor signalling in androgen-independent prostate cancer.
Kato Y1, Ochiai K2, Michishita M3, Azakami D1, Nakahira R3, Morimatsu M4, Ishiguro-Oonuma T5, Yoshikawa Y6, Kobayashi M7, Bonkobara M7, Kobayashi M8, Takahashi K3, Watanabe M9, Omi T1.

Cell Rep. 2015 Mar 31;10(12):1947-56. doi: 10.1016/j.celrep.2015.02.053. Epub 2015 Mar 19.
UHRF1 is a sensor for DNA interstrand crosslinks and recruits FANCD2 to initiate the Fanconi anemia pathway.
Liang CC1, Zhan B1, Yoshikawa Y1, Haas W2, Gygi SP2, Cohn MA3.
1: Co-first author

BMC Vet Res. 2015 Jul 23;11:159. doi: 10.1186/s12917-015-0483-9.
Reduced canine BRCA2 expression levels in mammary gland tumors.
Yoshikawa Y1, Morimatsu M2, Ochiai K3, Ishiguro-Oonuma T4, Wada S5, Orino K6, Watanabe K7.

Biometals. 2015 Aug;28(4):679-85. doi: 10.1007/s10534-015-9853-9. Epub 2015 Apr 10.
Analysis of the binding of bovine and human fibrinogen to ferritin: evidence that fibrinogen is a common ferritin-binding protein in mammals.
Okada A1, Yoshikawa Y, Watanabe K, Orino K.

Biomed Res. 2015;36(2):155-8. doi: 10.2220/biomedres.36.155.
Polymorphisms of canine BRCA2 BRC repeats affecting interaction with RAD51.
Ochiai K1, Ishiguro-Oonuma T, Yoshikawa Y, Udagawa C, Kato Y, Watanabe M, Bonkobara M, Morimatsu M, Omi T.

FEBS J. 2013 Dec;280(24):6600-12. doi: 10.1111/febs.12565. Epub 2013 Nov 1.
Autotaxin as a novel, tissue-remodeling-related factor in regressing corpora lutea of cycling rats.
Masuda K1, Haruta S, Orino K, Kawaminami M, Kurusu S.

Acta Vet Scand. 2013 Sep 22;55:70. doi: 10.1186/1751-0147-55-70.
The presence of heat-labile factors interfering with binding analysis of fibrinogen with ferritin in horse plasma.
Takahashi K1, Kondo T, Yoshikawa Y, Watanabe K, Orino K.

J Vet Med Sci. 2013 Dec 30;75(12):1615-8. Epub 2013 Jul 23.
Factors influencing measurement of serum iron concentration in dogs: diurnal variation and hyperferritinemia.
Chikazawa S1, Hori Y, Kanai K, Ito N, Hoshi F, Orino K, Watanabe K, Higuchi S.

Anim Sci J. 2013 Dec;84(12):782-9. doi: 10.1111/asj.12069. Epub 2013 Apr 18.
Change of antibody levels to ferritin in the sera of foals after birth: possible passive transfer of maternal anti-ferritin autoantibody via colostrum and age-related anti-ferritin autoantibody production.
Numata M1, Kondo T, Nambo Y, Yoshikawa Y, Watanabe K, Orino K.

Mol Biol Rep. 2013 Dec;40(12):6747-55. doi: 10.1007/s11033-013-2791-0. Epub 2013 Sep 26.
Selection of suitable reference genes for mRNA quantification studies using common marmoset tissues.
Shimamoto Y1, Kitamura H, Niimi K, Yoshikawa Y, Hoshi F, Ishizuka M, Takahashi E.

J Vet Med Sci. 2013 Nov;75(11):1419-26. Epub 2013 Jun 25.
Change in serum ferritin concentration in experimentally induced anemia of chronic inflammation in dogs.
Chikazawa S1, Nakazawa T, Hori Y, Hoshi F, Kanai K, Ito N, Orino K, Watanabe K, Higuchi S.

J. 2013 Sep;197(3):769-75. doi: 10.1016/j.tvjl.2013.0AAA4.024. Epub 2013 May 31.
Molecular cloning and tumour suppressor function analysis of canine REIC/Dkk-3 in mammary gland tumours.
Ochiai K1, Watanabe M, Azakami D, Michishita M, Yoshikawa Y, Udagawa C, Metheenukul P, Chahomchuen T, Aoki H, Kumon H, Morimatsu M, Omi T.

Anim Sci J. 2013 Jul;84(7):556-61. doi: 10.1111/asj.12034. Epub 2013 Jan 27.
Measurement of ferritin and anti-ferritin autoantibodies in serum and colostrum of Holstein and Japanese Black cows.
Kanno Y1, Ohtsuka H, Yoshikawa Y, Watanabe K, Orino K.

J Vet Med Sci. 2013;75(8):1101-5. Epub 2013 Apr 2.
Binding analysis of ferritin with heme using α-casein and biotinylated-hemin: detection of heme-binding capacity of Dpr derived from heme synthesis-deficient Streptococcus mutans.
Mieno A1, Yamamoto Y, Yoshikawa Y, Watanabe K, Mukai T, Orino K.

J Vet Med Sci. 2013 May 2;75(4):515-7. Epub 2012 Nov 13.
Development of a sandwich enzyme-linked immunosorbent assay to detect and measure serum levels of canine ferritin.
Chikazawa S1, Hori Y, Hoshi F, Kanai K, Ito N, Sato J, Orino K, Watanabe K, Higuchi S.

PLoS One. 2012;7(10):e45833. doi: 10.1371/journal.pone.0045833. Epub 2012 Oct 12.
Effects of the missense mutations in canine BRCA2 on BRC repeat 3 functions and comparative analyses between canine and human BRC repeat 3.
Yoshikawa Y1, Ochiai K, Morimatsu M, Suzuki Y, Wada S, Taoda T, Iwai S, Chikazawa S, Orino K, Watanabe K.

Biometals. 2012 Oct;25(5):1083-8. doi: 10.1007/s10534-012-9573-3. Epub 2012 Jul 24.
Iron-dependent binding of bovine milk α-casein with holo-lactoferrin, but not holo-transferrin.
Shibuya N1, Yoshikawa Y, Watanabe K, Ohtsuka H, Orino K.

BMC Res Notes. 2012 Apr 3;5:173. doi: 10.1186/1756-0500-5-173.
Establishment of a PCR analysis method for canine BRCA2.
Yoshikawa Y1, Morimatsu M, Ochiai K, Okuda K, Taoda T, Chikazawa S, Shimamura A, Omi T, Bonkobara M, Orino K, Watanabe K.

J Vet Med Sci. 2012 May;74(5):583-9. Epub 2011 Dec 19.
Effects of oxidative stress caused by tert-butylhydroquinone on cytotoxicity in MDCK cells.
Shibuya N1, Kobayashi S, Yoshikawa Y, Watanabe K, Orino K.

Biometals. 2011 Dec;24(6):1217-24. doi: 10.1007/s10534-011-9470-1. Epub 2011 Jul 6.
Heme-mediated binding of α-casein to ferritin: evidence for preferential α-casein binding to ferrous iron.
Usami A1, Tanaka M, Yoshikawa Y, Watanabe K, Ohtsuka H, Orino K.

Biometals. 2011 Dec;24(6):1123-31. doi: 10.1007/s10534-011-9471-0. Epub 2011 Jun 23.
Effect of diquat-induced oxidative stress on iron metabolism in male Fischer-344 rats.
Higuchi M1, Yoshikawa Y, Orino K, Watanabe K.

Poult Sci. 2011 Jul;90(7):1489-95. doi: 10.3382/ps.2010-01307.
Structural and functional analyses of chicken liver ferritin.
Watanabe M1, Yuge M, Uda A, Yoshikawa Y, Watanabe K, Orino K.

Biosci Biotechnol Biochem. 2011;75(3):496-9. Epub 2011 Mar 7.
Wheat bran protects Fischer-344 rats from diquat-induced oxidative stress by activating antioxidant system: selenium as an antioxidant.
Higuchi M1, Oshida J, Orino K, Watanabe K.

FEBS Lett. 2011 Jun 23;585(12):1771-7. doi: 10.1016/j.febslet.2011.05.027. Epub 2011 May 17.
Valine 1532 of human BRC repeat 4 plays an important role in the interaction between BRCA2 and RAD51.
Ochiai K1, Yoshikawa Y, Yoshimatsu K, Oonuma T, Tomioka Y, Takeda E, Arikawa J, Mominoki K, Omi T, Hashizume K, Morimatsu M.

J Vet Med Sci. 2011 Mar;73(3):313-8. Epub 2010 Oct 28.
Binding of mammalian and avian ferritins with biotinylated hemin: demonstration of preferential binding of the H subunit to heme.
Nakai M1, Murata N, Yoda T, Yoshikawa Y, Watanabe K, Orino K.

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